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Description
APE1 Polyclonal Antibody. Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases
Immunogen
n/a
Other Names
AP endonuclease 1; AP endonuclease class I; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; apurinic/apyrimidinic exonuclease; deoxyribonuclease (apurinic or apyrimidinic); multifunctional DNA repair enzyme; protein REF-1; redox factor 1