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Description
ACT1 Monoclonal Antibody (9ACT12), eBioscience?. This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expres
Immunogen
n/a
Other Names
RP3-487J7.3, ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, PSORS13; NFkB-activating protein ACT1; TRAF3-interacting protein 2; adapter protein CIKS; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1