Immunohistochemistry: 1:50-1:200, Western Blot: 0.4 μg/mL
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Description
CGREF1 Polyclonal Antibody. CGREF1 (cell growth regulator with EF-hand domain 1), also known as CGR11, is a 301 amino acid secreted protein that contains two highly conserved calcium binding EF-hand domains, which are required for mediating cell-cell adhesion. Induced by p53, CGREF1 is able to inhibit cell growth in various cell lines. CGREF1 is encoded by a gene located on human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstrom
Immunogen
n/a
Other Names
Cell growth regulator with EF hand domain protein 1, Cell growth regulatory gene 11 protein, Hydrophobestin, Cgref1, Cgr11