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Description
RON Polyclonal Antibody. Macrophage-stimulatin 1 receptor (MST1R/Ron), a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been im
Immunogen
n/a
Other Names
CD136, CDw136, PTK8, RON, MSP receptor, MST1R variant RON30, MST1R variant RON62, PTK8 protein tyrosine kinase 8, RON variant E2E3, c-met-related tyrosine kinase, macrophage-stimulating protein receptor, p185-Ron, soluble RON variant 1, soluble RON variant 2, soluble RON variant 3, soluble R