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Description
ATG16L1 Polyclonal Antibody. Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The process is found in eukaryotes, including yeast, and involves several genes and two novel ubiquitin-like conjugation systems. The APG12 system is one of the ubiquitin-like protein conjugation systems essential for autophagy. Covalent attachment of APG12-APG5 is essential for autophagy. In mammalian cells, the APG12-APG5 conjugate is a protein complex of approximately 800 kDa and includes an additional novel protein. This novel protein was designated APG16L (APG16-like, also referred to as ATG16L) as it's N-terminal region contains several features similar to yeast APG16. APG16L protein has several spliced isoform