A flavone that modulates xenobiotic metabolism; antagonizes AhR at nanomolar concentrations, although it agonizes AhR at higher concentrations (10 μM); inhibits CYP19, CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM)