HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. MW: 436.5. Purity ≥95%
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
(6R,?9S,?14aR)-?3,?6R-?dimethyl-?9S-?(6-?((S)-?oxiran-?2-?yl)-?6-?oxohexyl)decahydropyrrolo[1,?2-?a][1,?4,?7,?10]tetraazacyclododecine-?1,?4,?7,?10-?tetranone; Toxin I (Helminthosporium carbonum)