Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}