Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:500-1:3000
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
NTAN1 Polyclonal Antibody. Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position.
Immunogen
n/a
Other Names
N-terminal asparagine amidohydrolase, PNAA, PNAD, protein N-terminal Asn amidase, protein N-terminal asparagine amidohydrolase, protein NH2-terminal asparagine amidohydrolase, protein NH2-terminal asparagine deamidase, protein NTN-amidase