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Description
TRIF Polyclonal Antibody. Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Immunogen
n/a
Other Names
TICAM1;PRVTIRB; TRIF; TIR domain-containing adapter molecule 1; TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B; TIR domain-containing adapter molecule 1; Putative NF-kappa-B-activating protein 502H; TI