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Description
TNIP3 Polyclonal Antibody. The nuclear factor NF-kappa-B plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappa-B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappa-B inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slig
Immunogen
n/a
Other Names
ABIN-3, LIND; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3 beta; Listeria induced; TNFAIP3-interacting protein 3; TNFAIP3-interacting protein 3 beta; TNIP3 beta; listeria-induced gene protein