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Description
TRAF3IP2 Polyclonal Antibody. Nuclear factor kappa B (NF-kappa-B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B associates with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kappa-B activator 1). CIKS directly interacts with IKK-gamma. CIKS/Act1 also activate
Immunogen
n/a
Other Names
RP3-487J7.3, ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, PSORS13; NFkB-activating protein ACT1; TRAF3-interacting protein 2; adapter protein CIKS; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1