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Description
CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat, it can modulate acetylcholine receptor function at the neuromuscular junction, it has been demonstrated to block tolerance to morphine, and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I