Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:1000
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
HIPPI Monoclonal Antibody (OTI2G3). Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Immunogen
n/a
Other Names
ESRRBL1, HIPPI, MHS4R2, HIP1 protein interactor, HIP1-interacting protein, dermal papilla-derived protein 8, estrogen-related receptor beta like 1, estrogen-related receptor beta-like protein 1, huntingtin interacting protein-1 interacting protein, intraflagellar transport protein 57