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Description
HIPPI Polyclonal Antibody. Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Immunogen
n/a
Other Names
IFT57; intraflagellar transport 57 homolog (Chlamydomonas); ESRRBL1; FLJ10147; HIPPI; MHS4R2; HIP1 protein interactor; estrogen-related receptor beta like 1; huntingtin interacting protein-1 interacting protein