ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC50 = 0.85 μM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 = 0.4-0.8 μM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells. MW: 415.52. Purity ≥98% by HPLC