gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE) (N-Term), (Subunit delta)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
rat, mouse
Isotype
n/a
Format
affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (Frozen Sections) (IHC (fro))
Reviews / Ratings
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Description
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). More recently there have been a number of studies demonstrating that the d-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003, Wohlfarth et al., 2002). Anti-GABAA Receptor, d-Subunit Western blot of mouse cerebellar lysates from wild type (Control) and d-knockout (d-K/O) animals showing specific immunolabeling of the ~52k d-subunit of the GABAA-R. The labeling was absent from a lysate prepared from d-knockout animals.