An agonist of TrkB (IC50 = 47 nM in a fluorescence anisotropy assay); selectively inhibits BDNF binding to 3T3 cells expressing TrkB over those expressing TrkA, TrkC, or p75NTR; increases survival of hippocampal neurons in vitro, restores neurogenesis and improves cognitive deficits in mouse models of ischemic stroke, Huntington's disease, Rett syndrome, and a rat model of traumatic brain injury,