A peptide with diverse biological activities; reverses U-46619-induced increases in lobar arterial pressure in cats (10-3,000 ng per animal); reduces mechanical ventilation-induced lung injury and sepsis as well as liver and gut injury induced by ventilator-induced lung injury in a mouse model of pneumococcal pneumonia infection; improves survival and inhibits doxorubicin-induced cardiac tissue damage in mice; reduces hyperoxia-induced right ventricular hypertrophy and artery thickness in a rat model of bronchopulmonary dysplasia,