Purity >98%. Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means play. It has weak affinity for the human central cannabinoid (CB1 ) and peripheral cannabinoid (CB2 ) receptors, exhibiting 20% displacement of [3 H]-CP55940 at a concentration of 10 μM. Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 of 9.5 μM. Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.