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Description
Bcr (Tyr360) Polyclonal Antibody, Alexa Fluor? 647 Conjugated. ? Target Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Bcr around the phosphorylation site of Tyr360 [TT(p-Y)RM]