Follistatin is an autocrine acting protein that is expressed by many tissues, but at noteably higher levels in the ovary and skin. Follistatin functions to negatively regulate the signaling of a wide variety of TGF-beta family members (activin, BMPs, myostatin, GDF-11 and TGF-beta 1). Mechanistically, follistatin works as an antagonist by complexing with TGF-beta family members to prevent them from interacting with their signaling receptors. Recombinant mouse follistatin is a nonglycosylated protein, containing 289 amino acids, with a molecular weight of 31.6 kDa. MW: 31.6 kDa. Purity ≥90%
Size
100 μg
Concentration
n/a
Applications
RUO
Other Names
FS, activin-binding protein, FSH-suppressing protein (FSP)