NABP1, Recombinant, Human, aa1-204, His-Tag (Nucleic Acid Binding Protein 1)
Description
Purity ~95% (SDS-PAGE). Nucleic acid binding protein 1, also known as NABP1, is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Source: Recombinant protein corresponding to aa1-204 from human NABP1, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~24.8kD (227aa), confirmed by MALDI-TOF Applications: Suitable for use in SDS-PAGE.