Soluble Epoxide Hydrolase (EC 3.3.2.10) is a cytosolic enzyme with highest expression in the liver but present ubiquitously in several organs including the kidney, pancreatic islets, pituitary gland, lymphoid tissues, muscles, and the gastrointestinal tract. It catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), i.e., epoxides derived from cytochrome P-450 mediated metabolism of arachidonic acid, to form vicinal diols. The EETs cause vasodilation and have anti-inflammatory actions. Since the EETs are hydrolyzed to diols through soluble epoxide hydrolase, the inhibition of this enzyme is likely to enhance the beneficial properties of EETs. This makes soluble epoxide hydrolase a very useful target for cardiovascular and pain medicin